Controversy in organophosphate poisoning management

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Intensive care management of organophosphate insecticide poisoning

INTRODUCTION Organophosphate (OP) insecticides inhibit both cholinesterase and pseudo-cholinesterase activities. The inhibition of acetylcholinesterase causes accumulation of acetylcholine at synapses, and overstimulation of neurotransmission occurs as a result of this accumulation. The mortality rate of OP poisoning is high. Early diagnosis and appropriate treatment is often life saving. Treat...

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Organophosphate poisoning and management, an update.

Organophosphate poisoning is characterised for the most part, by acute incidents. Management is by way of first aid (in mild poisoning) and use of atropine with or without the oximes, (in moderate to severe poisoning). Of late, it has become apparent that subchronic and chronic organophosphate poisoning are a common manifestation. This review paper summarises this triphasic nature of organophos...

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Organophosphate Poisoning

They are used as pesticides but can also be used as 'nerve gas'. This is prohibited under the Geneva Convention but could be used by terrorists or rogue regimes. There is some suggestion that the use of OP pesticides may have caused some neurotoxicity and be responsible for 'Gulf War syndrome'. Certainly, insecticides were freely used, as were many other chemicals. The syndrome is inconsistent ...

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Organophosphate Poisoning

They are used as pesticides but can also be used as 'nerve gas'. This is prohibited under the Geneva Convention but could be used by terrorists or rogue regimes. There is some suggestion that the use of OP pesticides may have caused some neurotoxicity and be responsible for 'Gulf War syndrome'. Certainly, insecticides were freely used, as were many other chemicals. The syndrome is inconsistent ...

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Chronic organophosphate poisoning.

Prolonged exposure to organophosphates in low concentrations caused diarrhoea in 38 students, lecturers and other personnel at an agricultural college. The symptoms of those affected, plasma pseudocholinesterase levels, topography of the orchards and vegetable gardens, the various insecticides and quantities used, and the exposure due to prevailing winds have been studied. We conclude that safe...

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ژورنال

عنوان ژورنال: Indian Journal of Pharmacology

سال: 2007

ISSN: 0253-7613

DOI: 10.4103/0253-7613.33440